鄭重說明:

您值得信賴的中藥成分及標準合作伙伴滿足您研發(fā)和工業(yè)化需求

產品關鍵詞：香草酸-4-β-D-葡萄糖苷 6-甲氧基山奈酚茯苓新酸B 去甲異波爾定

guanyuwomen關于德思特

聯(lián)系方式

服務熱線：

028-8500-3950

公司傳真：	028-85589956
公司郵箱：	sales@tcmlmt.com
公司網址：	ipv16.com
公司地址：	四川省成都市溫江區(qū)?？坡肺鞫?28號5棟

發(fā)表文獻展示

當前位置:首頁關于德思特 > 發(fā)表文獻展示 >

Neurochemical Research-14 May 2020 羥基紅花黃色素A 78281-02-4

時間：2020-09-03 瀏覽次數：分享到：

afflower Yellow Improves the Synaptic Structural Plasticity by Ameliorating the Disorder of Glutamate Circulation in Aβ1-42-induced AD Model Rats

期刊名：Neurochemical Research
文獻編號：10.1007/s11064-020-03051-w
文獻地址：https://link.springer.com/article/10.1007/s11064-020-03051-w
發(fā)表日期：14 May 2020

Abstract

Safflower yellow (SY) is the main effective component of Carthamus tinctorius L., and Hydroxysafflor yellow A (HSYA) is the single active component with the highest content in SY. SY and HSYA have been shown to have neuroprotective effects in several AD models. In this study, we aimed to clarify whether the effects of SY and HSYA on the learning and memory abilities of Aβ1-42-induced AD model rats are related to the enhancement of synaptic structural plasticity in brain tissues and the amelioration of disorder of glutamate circulation. We used rats injected with Aβ1-42 into the bilateral hippocampus as a model of AD. After treatment with SY and HSYA, the learning and memory abilities of the Aβ1-42-induced AD model rats were enhanced, Aβ deposition in the AD model rats was decreased, structural damage to dendritic spines and the loss of synaptic-associated proteins were alleviated, and the disorder of glutamate circulation was ameliorated. The results indicated that SY and HSYA improve synaptic structural plasticity by ameliorating the disorder of glutamate circulation in Aβ1-42-induced AD model rats.

Hydroxysafor yellow A （HSYA purity>98%) was purchased from Chengdu DeSiTe Biological Technology Co., Ltd. (Sichuan, China).

上一篇：Chemosphere - 24 December 2019 異甘草素 CAS 961-29-5

下一篇：Acta Pharmaceutica Sinica B-6 May 2020 雷公藤甲素 38748-32-2

Afrormosine CAS:550-79-8 中藥對照品標準品

產品編碼：DA0040產品名稱：Afrormosine英文名:AfrormosineCAS登錄...